Metals | CYP450 effects | Potential substrates†| Reference |
---|---|---|---|
Cadmium | Induced 2A6 | Carbamates, drugs | [32] |
 | Induced 2E1 | Halogenated aliphates, triazines, organophosphates, VOCs, drugs | [32] |
 | Induced 2C9 | Drugs, organophosphates, triazines | [32] |
Lead | Inhibited 2A6 | Drugs | [63] |
 | Inhibited 1A2 (rats) | Arylamines, organophosphates, triazines, VOCs, PCBs, drugs | [64] |
Arsenic | Induced 1A1 (rats) | PAHs, VOCs, PCBs, triazines | |
Metal mixtures | Altered 1A1/2 induction by PAHs/TCDD (rats) | PAHs, VOCs, PCBs, triazines, organophosphates, drugs |