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Table 1 Selected interactions between metals and CYP450 enzymes in humans and animals

From: A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals

Metals

CYP450 effects

Potential substrates†

Reference

Cadmium

Induced 2A6

Carbamates, drugs

[32]

 

Induced 2E1

Halogenated aliphates, triazines, organophosphates, VOCs, drugs

[32]

 

Induced 2C9

Drugs, organophosphates, triazines

[32]

Lead

Inhibited 2A6

Drugs

[63]

 

Inhibited 1A2 (rats)

Arylamines, organophosphates, triazines, VOCs, PCBs, drugs

[64]

Arsenic

Induced 1A1 (rats)

PAHs, VOCs, PCBs, triazines

[65, 66]

Metal mixtures

Altered 1A1/2 induction by PAHs/TCDD (rats)

PAHs, VOCs, PCBs, triazines, organophosphates, drugs

[67, 68]

  1. †Substrate/P450 relationships from [24, 69–71].