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Figure 4 | Theoretical Biology and Medical Modelling

Figure 4

From: Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems

Figure 4

Local and distributed sources of robustness in protein systems designed according to purely redundant and purely degenerate G:P mappings. a) Differential robustness as a function of the percentage of genes that are mutated in each protein system. Differential robustness is defined as the probability for a system phenotype to maintain fitness after it was allowed to adjust to a change in conditions (here: gene mutations). Source: [43] b) Versatility-robustness as a function of initial excess protein resources. Versatility is measured as the number of null mutation combinations ("neutral network size") for which the system phenotype maintains fitness. Source: [43]. c) Frequency distribution for the proportion C of distinct gene products that change their function when versatility is evaluated (as of panel b experiments) in systems with 0% initial excess resources. d) Versatility of redundant and degenerate systems when the system response to null mutations is restricted to local compensation only; i.e. gene products can only change their functional contribution if they are directly related to those functions lost as a result of a null mutation.

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