Figure 4
Model 2. Top-Blue: Evolution of normal cells, Purple: Evolution of tumor cells. Common parameters: r N = 0.4, h = 105, γ = 0.083, K N = 106. Top left: there is no interaction between normal cells and tumor cells k = 0, β = 0. Tumor cells show a higher increasing rate at the beginning compared to the normal cells. Top right: normal and tumor cells are allowed to interact, k = 1, β = 2, ρ0 = 1, ρ1 = 1000, T* = 3.105, N0 = 1, T0 = 1. Fast growing tumor cells force the normal passes the critical size of tumor cells quickly and force normal cells enter to the inhibition phase in a short time. Down: The evolution of normal cells and tumor cells during the phase of therapy. The drug is considered to be static. Down Left: the drug does not have any effects on normal cells, a N (1 - emu) = 0, and a T (1 - emu) = 0.0 (Blue-untreated system), 0.1 (red), and 0.17 (green). Effect of the drug in slower growth of tumor cells and a delay in entering the inhibition phase for the normal cells can be detected.