Organized cluster mapping of DNA to Nucleus. Mapping of DNA strand into DNA Hard Drive: A) shows the DNA strand decomposed into its information structure. The top layer (gray) contain the strategic placement of insulators, the middle layer contains the regulatory control regions (red) that controls the copy process of the genes and the bottom layer contains the genes organized into a form that allows co-expression. B) Shows the mapping of the insulators to the nuclear lamin substrate to form insulator clusters. These cluster are placed such that they structurally partition the genes into organized clusters. The regulatory control regions (red) now become specific to the rosette pattern formed from the insulator clusters. This results in a rosette pattern of genes and their control regions. C) Shows the placement of the rosette patterns to the nuclear lamin substrate within the nucleus thus creating the DNA hard drive. The red lines indicate the lamin. Pictures B and C from Maya, Corces, Capelson and Victor, "Biology of the cell" with permission. Available online 09 September 2004.