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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Serotonin synthesis, release and reuptake in terminals: a mathematical model

Figure 5

Effects of 5-HT1A agonists and fluoxetine. Panel A shows the change in extracellular 5-HT in the hippocampus and the frontal cortex computed by the model after a 5-HT1A agonist is given. The curves are similar to those in [108]. Panel B shows model computations of the extracellular concentrations of 5-HT in the hippocampus and the frontal cortex after a dose of an SSRI (fluoxetine or paroxetine); the solid curves are wild type and the dashed curves are 5-HT1B knockouts. These curves should be compared to Figure one (10 mg/kg dose) in [106] and Figure one (a, b, c, d) in [109]. For discussion, see the text.

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