Effects of 5-HT1A agonists and fluoxetine. Panel A shows the change in extracellular 5-HT in the hippocampus and the frontal cortex computed by the model after a 5-HT1A agonist is given. The curves are similar to those in . Panel B shows model computations of the extracellular concentrations of 5-HT in the hippocampus and the frontal cortex after a dose of an SSRI (fluoxetine or paroxetine); the solid curves are wild type and the dashed curves are 5-HT1B knockouts. These curves should be compared to Figure one (10 mg/kg dose) in  and Figure one (a, b, c, d) in . For discussion, see the text.