Table 2 The Differential Equations

$\frac{d[bh2]}{dt}=V_{\text{TPH}}\left(trp,bh4,e5ht\right)–V_{\text{DRR}}\left(bh2,\text{NADPH},bh4,\text{NADP}\right)$

(7)

$\frac{d[bh4]}{dt}=V_{\text{DRR}}\left(bh2,\text{NADPH},bh4,\text{NADP}\right)–V_{\text{TPH}}\left(trp,bh4,e5ht\right)$

(8)

$\frac{d[trp]}{dt}=V_{trpin}\left(btrp\right)–V_{\text{TPH}}\left(trp,bh4,e5ht\right)–V_{trp-pool}\left(trp,trp–pool\right)$

(9)

$\frac{d[5htp]}{dt}=V_{\text{TPH}}\left(trp,bh\text{4},e\text{5}ht\right)–V_{\text{AADC}}\left(\text{5}htp\right)$

(10)

$\frac{d[c5ht]}{dt}=V_{\text{AADC}}\left(5htp\right)–V_{\text{MAT}}\left(c5ht,v5ht\right)+fluox\left(t\right)V_{\text{SERT}}\left(e5ht\right)–V_{c5ht}^{catab}(c5ht)$

(11)

$\frac{d[v5ht]}{dt}=V_{\text{MAT}}\left(c5ht,v5ht\right)–release\left(e5ht\right)fire\left(t\right)v5ht$

(12)

$\frac{d[e5ht]}{dt}=release\left(e5ht\right)fire\left(t\right)v5ht–fluox\left(t\right)V_{SERT}\left(e5ht\right)–V_{e5ht}^{catab}(e5ht)-V_{rem}(e5ht)$

(13)

$\frac{d[5hiaa]}{dt}=V_{c5ht}^{catab}(c5ht)+V_{e5ht}^{catab}(e5ht)-k_{hiaa}^{catab}.5hiaa$

(14)

$\frac{d[trp-pool]}{dt}=V_{trp–pool}(trp,trp-pool)-k_{trp-pool}^{catab}\cdot trp-pool$

(15)