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Table 3 Kinetic Parameters (μ M, μ M/hr,/hr).

From: Serotonin synthesis, release and reuptake in terminals: a mathematical model

velocity parameter model value literature value references
V AADC aromatic amino acid decarboxylase    
  k m 160 160 [121]
  V max 400   *
V SERT serotonin transporter    
  k m .17 0.05-1 [1, 46, 47]
  V max 8000   *
V DRR dihydropteridine reductase    
  K bh2 100 4-754 [122, 123]
  K NADPH 75 29-770 [124126]
  V max f 5000   *
  K bh 4 10 1.1-17 [125, 127]
  K NADP 75 29-770 [124126]
  V max b 3   *
V MAT vesicular monoamine transporter    
  K m .198 .123-.253 [65, 66]
  V max 3500   *
  k out 40   *
V TPH tryptophan hydroxylase    
  K trp 40 40 [64]
  K bh4 20 20 [64]
  V max 400   *
  K i (substrate inhibition) 1000 970 [64]
V trpin neutral amino acid transporter    
  K m 64 64 [55]
  V max 400   *
trp trp-pool    
  k 1 6   *
  k -1 0.6   *
  catabolism and diffusion    
  k t r p c a t a b 0.2   *
  V m a x c a t a b ( c 5 h t ) 1000   *
  K m c a t a b ( c 5 h t ) 95 94-95 [81, 82]
  V m a x c a t a b ( e 5 h t ) 1000   *
  K m c a t a b ( e 5 h t ) 95 94-95 [81, 82]
  k h i a a c a t a b 1 .82 [83]
  k t r p p o o l c a t a b 0.2   *
  k rem 400   *
  1. * see text