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Table 3 Kinetic Parameters (μ M, μ M/hr,/hr).

From: Serotonin synthesis, release and reuptake in terminals: a mathematical model

velocity

parameter

model value

literature value

references

V AADC

aromatic amino acid decarboxylase

   
 

k m

160

160

[121]

 

V max

400

 

*

V SERT

serotonin transporter

   
 

k m

.17

0.05-1

[1, 46, 47]

 

V max

8000

 

*

V DRR

dihydropteridine reductase

   
 

K bh2

100

4-754

[122, 123]

 

K NADPH

75

29-770

[124–126]

 

V max f

5000

 

*

 

K bh 4

10

1.1-17

[125, 127]

 

K NADP

75

29-770

[124–126]

 

V max b

3

 

*

V MAT

vesicular monoamine transporter

   
 

K m

.198

.123-.253

[65, 66]

 

V max

3500

 

*

 

k out

40

 

*

V TPH

tryptophan hydroxylase

   
 

K trp

40

40

[64]

 

K bh4

20

20

[64]

 

V max

400

 

*

 

K i (substrate inhibition)

1000

970

[64]

V trpin

neutral amino acid transporter

   
 

K m

64

64

[55]

 

V max

400

 

*

trp ↔

trp-pool

   
 

k 1

6

 

*

 

k -1

0.6

 

*

 

catabolism and diffusion

   
 

k t r p c a t a b

0.2

 

*

 

V m a x c a t a b ( c 5 h t )

1000

 

*

 

K m c a t a b ( c 5 h t )

95

94-95

[81, 82]

 

V m a x c a t a b ( e 5 h t )

1000

 

*

 

K m c a t a b ( e 5 h t )

95

94-95

[81, 82]

 

k h i a a c a t a b

1

.82

[83]

 

k t r p − p o o l c a t a b

0.2

 

*

 

k rem

400

 

*

  1. * see text