From: Serotonin synthesis, release and reuptake in terminals: a mathematical model
velocity | parameter | model value | literature value | references |
---|---|---|---|---|
V AADC | aromatic amino acid decarboxylase | Â | Â | Â |
 | k m | 160 | 160 | [121] |
 | V max | 400 |  | * |
V SERT | serotonin transporter | Â | Â | Â |
 | k m | .17 | 0.05-1 | |
 | V max | 8000 |  | * |
V DRR | dihydropteridine reductase | Â | Â | Â |
 | K bh2 | 100 | 4-754 | |
 | K NADPH | 75 | 29-770 | |
 |
| 5000 | Â | * |
 | K bh 4 | 10 | 1.1-17 | |
 | K NADP | 75 | 29-770 | |
 |
| 3 | Â | * |
V MAT | vesicular monoamine transporter | Â | Â | Â |
 | K m | .198 | .123-.253 | |
 | V max | 3500 |  | * |
 | k out | 40 |  | * |
V TPH | tryptophan hydroxylase | Â | Â | Â |
 | K trp | 40 | 40 | [64] |
 | K bh4 | 20 | 20 | [64] |
 | V max | 400 |  | * |
 | K i (substrate inhibition) | 1000 | 970 | [64] |
V trpin | neutral amino acid transporter | Â | Â | Â |
 | K m | 64 | 64 | [55] |
 | V max | 400 |  | * |
trp ↔ | trp-pool |  |  |  |
 | k 1 | 6 |  | * |
 | k -1 | 0.6 |  | * |
 | catabolism and diffusion |  |  |  |
 |
| 0.2 | Â | * |
 |
| 1000 | Â | * |
 |
| 95 | 94-95 | |
 |
| 1000 | Â | * |
 |
| 95 | 94-95 | |
 |
| 1 | .82 | [83] |
 |
| 0.2 | Â | * |
 | k rem | 400 |  | * |