Serotonin synthesis, release and reuptake in terminals: a mathematical model

Table 3 Kinetic Parameters (μ M, μ M/hr,/hr).

velocity	parameter	model value	literature value	references
V _AADC	aromatic amino acid decarboxylase
	k _m	160	160	[121]
	V _max	400		*
V _SERT	serotonin transporter
	k _m	.17	0.05-1	[1, 46, 47]
	V _max	8000		*
V _DRR	dihydropteridine reductase
	K _bh2	100	4-754	[122, 123]
	K _NADPH	75	29-770	[124–126]
	$V max f$	5000		*
	K _{bh 4}	10	1.1-17	[125, 127]
	K _NADP	75	29-770	[124–126]
	$V max b$	3		*
V _MAT	vesicular monoamine transporter
	K _m	.198	.123-.253	[65, 66]
	V _max	3500		*
	k _out	40		*
V _TPH	tryptophan hydroxylase
	K _trp	40	40	[64]
	K _bh4	20	20	[64]
	V _max	400		*
	K_i(substrate inhibition)	1000	970	[64]
V _trpin	neutral amino acid transporter
	K _m	64	64	[55]
	V _max	400		*
trp ↔	trp-pool
	k ₁	6		*
	k _-1	0.6		*
	catabolism and diffusion
	$k t r p c a t a b$	0.2		*
	$V m a x c a t a b (c 5 h t)$	1000		*
	$K m c a t a b (c 5 h t)$	95	94-95	[81, 82]
	$V m a x c a t a b (e 5 h t)$	1000		*
	$K m c a t a b (e 5 h t)$	95	94-95	[81, 82]
	$k h i a a c a t a b$	1	.82	[83]
	$k t r p − p o o l c a t a b$	0.2		*
	k _rem	400		*

ISSN: 1742-4682