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Table 4 Steady State Values from WT to SERT KO

From: Serotonin synthesis, release and reuptake in terminals: a mathematical model

  f* = 1(WT) f= .5 f= .2 f= .1 f= .05 f= 0(SERT KO)
trp 20.1 20.9 21.1 21.1 21.2 21.3
c 5 - HT 0.5 0.39 0.3 0.25 0.19 0.05
v 5 - HT 21.5 19.9 18.1 17.05 14.67 6.41
e 5 - HT ** .7 1.18 1.82 2.26 3.32 6.2
5 - hiaa 5.3 4.12 3.13 2.7 1.99 0.63
V TPH 5.57 4.59 3.86 3.6 3.32 3.12
V MAT 21.4 16.7 10.7 7.09 5.87 2.56
V SERT 21.1 16.2 9.93 6.16 4.5 0.0
V rem 0.31 0.47 0.73 0.9 1.33 2.50
V catab 5.26 4.12 3.13 2.7 1.99 0.63
  1. * f is the fraction of SERTs that are functional.
  2. ** concentration in nM, all other concentrations in μ M. Velocities have units μ M/hr.