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Figure 10 | Theoretical Biology and Medical Modelling

Figure 10

From: Pathological axes of wound repair: Gastrulation revisited

Figure 10

Schematic representation of the gastrulation process (top) and of a skin wound (bottom). The hypothetical functional reactivation of embryonic development axes after a tissue injury would reproduce the embryonic biochemical pathways in the mature organism. e: epiblast; eh: endothelial-hematopoietic cell lineages; ep: epithelium; EMT/MET: epithelial mesenchymal transition/mesenchymal epithelial transition; f: fibroblast; HP: hyperpigmentation; m: melanocyte; my: myofibroblast; n:neuron; nc: neural crest cell; NI:neuronal inflammation; nt: neural tube; not: notochord; p: pericyte; skm: skeletal muscle; v:blood vessels; VI: vascular inflammation;

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