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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: A danger of low copy numbers for inferring incorrect cooperativity degree

Figure 1

Fraction of bound proteins (Poisson initial state). A dose-response curve (the fraction of the bound proteins φ plotted as a function of a) for a Poisson-like ensemble: L 0 2 = L02 + L0 and P 0 2 = P02 + P0. Each curve is obtained by varying L0 for a fixed value of P0. The thickest full line is the reference Hill curve φ H (a), plotted with K = 1, depicting the mean field limit. The shape of the curve does not depend on the values of the ensemble parameters L0 and P0. The thin curves are fluctuation-corrected dose-response graphs obtained using the PARNES method. The full line was obtained with P0 = 1, the dashed line with P0 = 2, and the dotted line with P0 = 4. The curves that account for noise (thinner curves) approach the reference mean field curve from below for large values of P0 but are distinct otherwise.

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