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Table 2 Effect of differing relative rates of increase on clonal evolution.

From: Population genetics of cancer cell clones: possible implications of cancer stem cells

rA - ra

Number of generations needed for the relative proportion of a clone to change from 1% to 99%

0.01

919

0.05

184

0.10

92

0.50

18

0.75

12

1.00

9

2.00

5

5.00

2

  1. Number of cell generations required in a two clone model for a clone to go from a relative proportion of 1% to a relative proportion of 99% given a range of differences in the intrinsic rate of increase of the two clones. rA - ra = the intrinsic rate of increase of clone A minus the intrinsic rate of increase of clone a. See text for further explanation.