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Figure 15 | Theoretical Biology and Medical Modelling

Figure 15

From: Modeling CICR in rat ventricular myocytes: voltage clamp studies

Figure 15

Ryanodine receptor open probability. Figure 15: RyR open probability modulation by concentration at the mouth. The pre-release diastolic [Ca2+] jSR is 918 μ M. The stimulation protocol used is a pulse of amplitude (-40 mv to 10 mv) and duration (50 ms). Phase A - As a result of excitation by the trigger current, [Ca2+] ryr initially increases rapidly with a small accompanying rise in RyR open probability followed by steeper increase to peak [Ca2+] ryr with a large increase in RyR open probability.; Phase B - RyR open probability increases to its maximum value at a declining rate reflecting a falling [Ca2+] ryr level and onset of Ca2+ induced self-inhibition; Phase C - Decreasing Ca2+ dyad and continued Ca2+ induced self-inhibition, begins the channel recovery process; Phase D - Decreasing [Ca2+] jSR forces a strong RyR inactivation via the luminal sensor hence robustly closing the channel.

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