Effects of the application of caffeine. Figure 17: Model-simulated effects of the application of caffeine on ICa,L,TTand [Ca2+]
in a cell dialyzed with 2 mM Fura-2. Changes in [Ca2+]
resulting from: (A) application of a simple depolarizing pulse from -40 mV to 0 mV, and (B) the same depolarizing pulse following pre-exposure to caffeine (5 mM). Panel (C) compares the I
waveforms associated with these protocols. This model-generated result shows similarity to data in Figure 3, Adachi-Akahane et al. .