Figure 18
From: Modeling CICR in rat ventricular myocytes: voltage clamp studies
Effects of the application of Thapsigargin. Figure 18: In rat ventricular myocytes dialyzed with 2 mM Fura-2, thapsigargin gradually abolishes [Ca2+] myo transients and decreases the rate of inactivation of I Ca,L . This result is generated by the model, in response to a pulse train of amplitude (-40 mV to 0 mV), duration (0.1 sec) and frequency of 0.05 Hz. (A) Time course of the effect of thapsigargin on Δ[Ca2+]i. (B) L-type Ca2+ currents at the times indicated in (A). This model-generated result shows similarity to data in Figure 11, Adachi-Akahane et al. [71]