Figure 19
From: Modeling CICR in rat ventricular myocytes: voltage clamp studies
Effects of modulating [Ca2+] o . Figure 19: The effects of changing external Ca2+ concentration on cytoplasmic Ca2+ and SR Ca2+ content. The stimulation protocol used is a pulse train of amplitude (-40 mv to 0 mv), duration (100 ms) and frequency of 0.5 Hz. (A) Following sudden rise in [Ca2+] o the instantaneous increase in [Ca2+] myo occurs due to more Ca entry, followed by a gradual staircase rise due to the the change in SR content; (B) Changes in [Ca2+] myo forced by a sudden decrease in [Ca2+] o ; (C) Changes in [Ca2+] jSR due to increased [Ca2+] o ; (D) Changes in [Ca2+] jSR due to reduced [Ca2+] o . This model-generated result shows similarity to data in Figure 2, Diaz et al. [110].