Figure 5From: Modeling CICR in rat ventricular myocytes: voltage clamp studiesSchematic of the CICR subsystem. Figure 5: Schematic of the CICR subsystem. The dyadic coupling unit comprises of a DHP-sensitive Ca2+ channel opposing a Ry-sensitive Ca2+ channel. The transmembrane proteins triadin and junction along with calsequestrin mediate the interaction between the luminal Ca2+ and the RyR thus regulating the release of Ca2+ flux from the jSR into the dyadic space.Back to article page