Schematic of the Dyadic nanodomain. Figure 6: Schematic of the LCC-RyR coupling. The dyadic cleft allows Ca2+ signaling between a DHP-sensitive Ca2+ channel opposing a cluster of Ry-sensitive Ca2+ channels (represented as the release channel i
in our model). The trigger sparklet due to Ca2+ entering via DHP-sensitive iCa,L,TTchannel causes a spark as a result of release from a cluster of opposing RyR channels. The large amount of Ca2+ released subsequently diffuses into the cytosol.