Figure 6

Schematic of the Dyadic nanodomain. Figure 6: Schematic of the LCC-RyR coupling. The dyadic cleft allows Ca²⁺ signaling between a DHP-sensitive Ca²⁺ channel opposing a cluster of Ry-sensitive Ca²⁺ channels (represented as the release channel i _RyR in our model). The trigger sparklet due to Ca²⁺ entering via DHP-sensitive i_Ca,L,TTchannel causes a spark as a result of release from a cluster of opposing RyR channels. The large amount of Ca²⁺ released subsequently diffuses into the cytosol.