Figure 7

I _Ca,L & [Ca²⁺] _myo - comparison of model generated and experimental data in the positive voltage range. Figure 7: Model generated and experimentally obtained data from a rat ventricular myocyte clamped to voltages between 10 and 40 mv in steps of 10 mv. The holding potential used is -40 mv. Data is obtained from Dr. Philip. T. Palade's lab. (A) I_Ca,Lin the presence of Ca²⁺ release from the Ry-sensitive channel. The pulse duration used is 50 ms. (B) I_Ca,Lwith Ryanodine administered to block RyR release. The pulse duration used is 200 ms. (C) Global cytosolic calcium transients [Ca²⁺] _myo in the presence of RyR release. The pulse duration used is 50 ms (D) I_Ca,Lusing Barium as the charge carrier in the absence of RyR. The pulse duration used is 200 ms. Solid traces are the model-generated results and dotted lines represent the data