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Table 2 Parameters used to model sub-cellular morphology

From: Modeling CICR in rat ventricular myocytes: voltage clamp studies

Parameter

Definition

Value

References

N dyad

Number of dyadic units

10000

[8]‡

V myo

Myoplasmic volume

5.3581 × 10-2 nL

[16]†

V LSR

Longitudinal SR volume

1.1776 × 10-3 nL

[16]*

∑ N d y a d V j S R

Total junctional SR volume

1.104 × 10-4 nL

[16]*

Δr

Step size in the 'r' direction

10 nm

Numerical solution†

d

Diameter of the cylindrical cleft space in the 'r' direction

400 nm

[119, 8, 120, 121, 6]‡

Δz

Step size in the 'z' direction

0.76 nm

Numerical solution†

h

Length of the cylindrical cleft space in the 'z' direction

15.2 nm

[119, 8, 120, 121, 6]‡

V cleft

Volume of a unit dyadic space

1.91 × 10-9 nL

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  1. Table 2: Parameters used to model sub-cellular morphology. Adopted (*), derived (†) or estimated (‡) from the cited sources.