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Table 9 Initial Conditions

From: Modeling CICR in rat ventricular myocytes: voltage clamp studies

State variable Definition Initial Value
[Ca2+] myo Ca2+ concentration in the myoplasm 8.1027 × 10-5 mM
[Ca2+] jSR Ca2+ concentration in jSR 1.2677 mM
[Ca2+] LSR Ca2+ concentration in LSR 1.3346 mM
[Na+] myo Na+ concentration in myoplasm 16.746 mM
[Na+] dyad Na+ concentration in dyadic space 16.321 mM
[Cs+] myo Cs+ concentration in myoplasm 140.2154 mM
[Cs+] dyad Cs+ concentration in dyadic space 140.2157 mM
O c Fractional occupancy of Calmodulin by Ca2+ 0.033091
O tc Fractional occupancy of Troponin by Ca2+ 0.016049
O tmgc Fractional occupancy of Troponin by Mg2+ and Ca2+ 0.321764
O tmgmg Fractional occupancy of Troponin by Mg2+ 0.598385
[CaF 3] Concentration of Fluo3-Ca2+ complex 21.88721 μM
C 1 ryr Closed (resting) state of RyR channel 0.9990953
O 2 ryr Open (activated) state of RyR channel 1.03668 × 10-9
C 3 ryr Inactivated state of RyR channel 9.38711 × 10-13
C 1 dhpr Closed (resting) state of DHPR sensitive Ca2+ channel 0.1673614
O 2 dhpr Open (activated) state of DHPR sensitive Ca2+ channel 1.499173 × 10-3
O 3 dhpr Open (activated) state of DHPR sensitive Ca2+ channel 3.300291 × 10-3
C 4 dhpr Closed (resting) state of DHPR sensitive Ca2+ channel 7.478058 × 10-8
C 6 dhpr Closed (resting) state of DHPR sensitive Ca2+ channel 7.478058 × 10-8
A 1 ls Fraction of Tr/J bound to RyR 0.6709816
I 2 ls Fraction of Tr/J bound to RyR and Calsequestrin 0.155258
I 3 ls Fraction of Tr/J bound only to Calsequestrin 0.0623695
B 6 ls Fraction Calsequestrin bound to Ca2+ 0.619346
[Ca2+] serca Ca bound to the serca protein 36.0637 × 10-5μM
S 2 dhpr Fraction of IQ Motif bound to Ca4CaM 6.816729 × 10-2
PLB dp Fraction of unphosphorylated Phospholamban 7.684160 × 10-2
Ca 2 CaM 2 Ca2+ ions bound to C-terminus of CaM 34.56529
Ca 4 CaM 4 Ca2+ ions bound to C & N terminus of CaM 8.635052 × 10-2
CaMB Buffered CaM 7.563836 × 10-2
Ca 2 CaMB Buffered Ca2CaM 2.035086
Ca 4 CaMB Buffered Ca 4CaM 1.288455 × 10-6
Ca 4 CaN CaN bound to 4 Ca 2+ ions 2.606246 × 10-4μM
CaMCaN CaN bound to CaM 4.348535 × 10-3μM
Ca 2 CaMCaN CaN bound to 2 Ca2+ ions and CaM 1.419613 × 10-1μM
Ca 4 CaMCaN CaN bound to 4 Ca2+ ions and CaM 3.473412μM
[Ca2+] dyad Ca2+ concentration in the dyadic space 9.012 × 10-5 mM  
  1. Table 9: Initial conditions used for the state vector in order to solve the linearized system of ordinary differential equations