Table 9 Initial Conditions
From: Modeling CICR in rat ventricular myocytes: voltage clamp studies
State variable | Definition | Initial Value | |
|---|---|---|---|
[Ca2+] myo | Ca2+ concentration in the myoplasm | 8.1027 × 10-5 mM | |
[Ca2+] jSR | Ca2+ concentration in jSR | 1.2677 mM | |
[Ca2+] LSR | Ca2+ concentration in LSR | 1.3346 mM | |
[Na+] myo | Na+ concentration in myoplasm | 16.746 mM | |
[Na+] dyad | Na+ concentration in dyadic space | 16.321 mM | |
[Cs+] myo | Cs+ concentration in myoplasm | 140.2154 mM | |
[Cs+] dyad | Cs+ concentration in dyadic space | 140.2157 mM | |
O c | Fractional occupancy of Calmodulin by Ca2+ | 0.033091 | |
O tc | Fractional occupancy of Troponin by Ca2+ | 0.016049 | |
O tmgc | Fractional occupancy of Troponin by Mg2+ and Ca2+ | 0.321764 | |
O tmgmg | Fractional occupancy of Troponin by Mg2+ | 0.598385 | |
[CaF 3] | Concentration of Fluo3-Ca2+ complex | 21.88721 μM | |
C 1 ryr | Closed (resting) state of RyR channel | 0.9990953 | |
O 2 ryr | Open (activated) state of RyR channel | 1.03668 × 10-9 | |
C 3 ryr | Inactivated state of RyR channel | 9.38711 × 10-13 | |
C 1 dhpr | Closed (resting) state of DHPR sensitive Ca2+ channel | 0.1673614 | |
O 2 dhpr | Open (activated) state of DHPR sensitive Ca2+ channel | 1.499173 × 10-3 | |
O 3 dhpr | Open (activated) state of DHPR sensitive Ca2+ channel | 3.300291 × 10-3 | |
C 4 dhpr | Closed (resting) state of DHPR sensitive Ca2+ channel | 7.478058 × 10-8 | |
C 6 dhpr | Closed (resting) state of DHPR sensitive Ca2+ channel | 7.478058 × 10-8 | |
A 1 ls | Fraction of Tr/J bound to RyR | 0.6709816 | |
I 2 ls | Fraction of Tr/J bound to RyR and Calsequestrin | 0.155258 | |
I 3 ls | Fraction of Tr/J bound only to Calsequestrin | 0.0623695 | |
B 6 ls | Fraction Calsequestrin bound to Ca2+ | 0.619346 | |
[Ca2+] serca | Ca bound to the serca protein | 36.0637 × 10-5μM | |
S 2 dhpr | Fraction of IQ Motif bound to Ca4CaM | 6.816729 × 10-2 | |
PLB dp | Fraction of unphosphorylated Phospholamban | 7.684160 × 10-2 | |
Ca 2 CaM | 2 Ca2+ ions bound to C-terminus of CaM | 34.56529 | |
Ca 4 CaM | 4 Ca2+ ions bound to C & N terminus of CaM | 8.635052 × 10-2 | |
CaMB | Buffered CaM | 7.563836 × 10-2 | |
Ca 2 CaMB | Buffered Ca2CaM | 2.035086 | |
Ca 4 CaMB | Buffered Ca 4CaM | 1.288455 × 10-6 | |
Ca 4 CaN | CaN bound to 4 Ca 2+ ions | 2.606246 × 10-4μM | |
CaMCaN | CaN bound to CaM | 4.348535 × 10-3μM | |
Ca 2 CaMCaN | CaN bound to 2 Ca2+ ions and CaM | 1.419613 × 10-1μM | |
Ca 4 CaMCaN | CaN bound to 4 Ca2+ ions and CaM | 3.473412μM | |
[Ca2+] dyad | Ca2+ concentration in the dyadic space | 9.012 × 10-5 mM |  |