Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space

Table 1 Statistics on overall state senstivities from local perturbation experiments for the transcriptional output Tnfα. Values shown were averaged over the ensemble of 10 reference parameter configurations evaluated. Mean-D (mean D Statistic); SD-D (standard deviation of D Statistic)

Parameter	ΔP= 10%	ΔP= 20%	ΔP= 30%	ΔP= 40%	ΔP= 50%	Mean-D	SD-D
Kb	0.003369	0.002241	0.001876	0.001177	0.000868	0.001906	0.002154
n	0.001355	0.0007648	0.0006529	0.001581	0.000949	0.001060	0.001100
k 21cat	0.001128	0.001713	0.000659	0.000536	0.000595	0.000926	0.001031
k 22f	0.001314	0.001137	0.000969	0.000379	0.000388	0.000837	0.001662
k 16r	0.001292	0.001043	0.000711	0.000502	0.000401	0.000790	0.001557
k 23cat	0.001019	0.001376	0.000464	0.000386	0.000461	0.000741	0.001361
kps	0.001065	0.000997	0.000536	0.000436	0.000414	0.000690	0.001315
k 33r	0.001334	0.000744	0.000484	0.000487	0.000373	0.000685	0.001388
k 23r	0.000434	0.001110	0.000619	0.000768	0.000299	0.000646	0.000998
k 19r	0.001099	0.000706	0.000749	0.000332	0.000288	0.000635	0.001372
k 7r	0.001191	0.000658	0.000469	0.000422	0.000324	0.000613	0.001395
k 23f	0.001247	0.000569	0.000588	0.000358	0.000284	0.000609	0.001382
k 18r	0.000668	0.000753	0.000676	0.000545	0.000345	0.000597	0.000918
k 31f	0.000721	0.000701	0.000571	0.000461	0.000453	0.000581	0.001235
k 32f	0.000480	0.000857	0.000546	0.000561	0.000429	0.000574	0.000904
k 24	0.001064	0.000625	0.000520	0.000304	0.000266	0.000556	0.001329
k 35r	0.001483	0.001000	0.000117	0.000105	0.0000739	0.000556	0.001630
ksa	0.000919	0.000725	0.000464	0.000314	0.000251	0.000535	0.001119
k 8	0.000638	0.000616	0.000533	0.000559	0.000183	0.000506	0.000873
k 14r	0.001026	0.000601	0.000251	0.000245	0.000340	0.000493	0.000748

ISSN: 1742-4682