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Table 1 Statistics on overall state senstivities from local perturbation experiments for the transcriptional output Tnfα. Values shown were averaged over the ensemble of 10 reference parameter configurations evaluated. Mean-D (mean D Statistic); SD-D (standard deviation of D Statistic)

From: Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space

Parameter ΔP= 10% ΔP= 20% ΔP= 30% ΔP= 40% ΔP= 50% Mean-D SD-D
Kb 0.003369 0.002241 0.001876 0.001177 0.000868 0.001906 0.002154
n 0.001355 0.0007648 0.0006529 0.001581 0.000949 0.001060 0.001100
k 21cat 0.001128 0.001713 0.000659 0.000536 0.000595 0.000926 0.001031
k 22f 0.001314 0.001137 0.000969 0.000379 0.000388 0.000837 0.001662
k 16r 0.001292 0.001043 0.000711 0.000502 0.000401 0.000790 0.001557
k 23cat 0.001019 0.001376 0.000464 0.000386 0.000461 0.000741 0.001361
kps 0.001065 0.000997 0.000536 0.000436 0.000414 0.000690 0.001315
k 33r 0.001334 0.000744 0.000484 0.000487 0.000373 0.000685 0.001388
k 23r 0.000434 0.001110 0.000619 0.000768 0.000299 0.000646 0.000998
k 19r 0.001099 0.000706 0.000749 0.000332 0.000288 0.000635 0.001372
k 7r 0.001191 0.000658 0.000469 0.000422 0.000324 0.000613 0.001395
k 23f 0.001247 0.000569 0.000588 0.000358 0.000284 0.000609 0.001382
k 18r 0.000668 0.000753 0.000676 0.000545 0.000345 0.000597 0.000918
k 31f 0.000721 0.000701 0.000571 0.000461 0.000453 0.000581 0.001235
k 32f 0.000480 0.000857 0.000546 0.000561 0.000429 0.000574 0.000904
k 24 0.001064 0.000625 0.000520 0.000304 0.000266 0.000556 0.001329
k 35r 0.001483 0.001000 0.000117 0.000105 0.0000739 0.000556 0.001630
ksa 0.000919 0.000725 0.000464 0.000314 0.000251 0.000535 0.001119
k 8 0.000638 0.000616 0.000533 0.000559 0.000183 0.000506 0.000873
k 14r 0.001026 0.000601 0.000251 0.000245 0.000340 0.000493 0.000748