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Table 2 Statistics on Overall State Senstivities from Local Perturbations Experiments for the Transcriptional Output Cxcl10. Values shown were averaged over the ensemble of 10 reference parameter configurations evaluated. Mean-D (mean D Statistic); SD-D (standard deviation of D Statistic)

From: Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space

Parameter

Ī”P= 10%

Ī”P= 20%

Ī”P= 30%

Ī”P= 40%

Ī”P= 50%

Mean-D

SD-D

Kb

0.007726

0.005217

0.006069

0.004233

0.004070

0.005463

0.007836

n

0.005616

0.004478

0.003862

0.003824

0.003714

0.004299

0.007452

k 40f

0.002317

0.002146

0.002607

0.002518

0.002238

0.002365

0.006197

k 42f

0.003415

0.002004

0.001858

0.001902

0.001834

0.002203

0.004786

k 21cat

0.002860

0.002644

0.001749

0.001634

0.001206

0.002019

0.002098

k 16r

0.004237

0.002285

0.001129

0.000868

0.000731

0.001850

0.002971

kps

0.003663

0.002090

0.001305

0.001196

0.000839

0.001819

0.002631

k 23cat

0.003425

0.002015

0.001266

0.001124

0.000651

0.001696

0.002657

k 33r

0.003194

0.002201

0.001196

0.001030

0.000760

0.001676

0.002669

k 23f

0.003989

0.002014

0.001034

0.000723

0.000590

0.001670

0.002982

k 19r

0.002917

0.001721

0.001572

0.000947

0.000739

0.001579

0.002649

k 8

0.002686

0.001737

0.001478

0.000968

0.000540

0.001482

0.002459

k 22f

0.002733

0.001615

0.000998

0.001147

0.000826

0.001464

0.002661

k 23r

0.002807

0.001821

0.001181

0.000786

0.000697

0.001458

0.002383

k 7r

0.002639

0.001675

0.001317

0.000935

0.000648

0.001443

0.002659

k 32f

0.001537

0.002349

0.001265

0.001116

0.000824

0.001418

0.001876

k 24

0.002710

0.001463

0.001237

0.000729

0.000597

0.001347

0.002629

kas

0.001528

0.002123

0.001111

0.000830

0.000810

0.001280

0.002070

k 1r

0.001324

0.001825

0.001397

0.000960

0.000753

0.001252

0.001656

k 18r

0.001279

0.001625

0.001444

0.000881

0.000708

0.001187

0.001692