A simple intravenous glucose tolerance test for assessment of insulin sensitivity

Table 2 Linear correlations between the IVGTT and the glucose clamp.

Y	X	Equation	Time period	r²	25^th-75^th percentiles of prediction error
M_bw		Y = -172 + 1040 X	75 min	0.63	-10%	+16%
		Y = -201 + 1179 X	40 min	0.63	-8%	+20%
		Y = -219 + 1256 X	30 min	0.62	-12%	+26%
	Same equation, but using total insulin AUC	Y = -220 + 1310 X	75 min	0.68	-11%	+9%
		Y = -218 + 1287 X	40 min	0.63	-8%	+12%
		Y = -248 + 1419 X	30 min	0.66	-8%	+20%
M_bw		Y = -19 +124 X	Baseline "Quicki"	0.41	-14%	+11%
M_bw	S_I of MINMOD 10^-5	Y = 36 + 0.38 X	75 min	0.34	-16%	+24%

Equations compare the cellular uptake of glucose obtained by the glucose clamp (M_bw,; μmol min^-1 kg^-1) and indices of glucose kinetics and plasma insulin obtained during an intravenous glucose tolerance test (IVGTT) in 20 non-obese volunteers.
T_1/2 = half-life of exogenous glucose (units: min)
Glucose_o, Ins_o = plasma concentrations of glucose and insulin at baseline (units: mmol L^-1 and pmol L^-1)
AUC_ins = area under the curve for plasma insulin over time (unit: pmol min L^-1)
MINMOD = "minimal model analysis" according to Bergman et al. [6]

ISSN: 1742-4682