From: Insights gained from the reverse engineering of gene networks in keloid fibroblasts
Binding Motif | Possible gene targets | Possible TFs |
---|---|---|
GGAGGG | EPO (erythropoietin) | Tf-LF1 and Tf-LF2 |
 | ATF2 (activating transcription factor 2) | SP1 |
 | RARG (retinoic acid receptor, gamma) | SP1 |
 | ACTC1 (actin, alpha, cardiac muscle 1) | SP1 |
 | FN (fibronectin) | - |
 | c-myc | Pur factor |
 | CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) | SP1 |
 | CYP17 (cytochrome P450, subfamily XVII) | PBX1B |
 | SFTPB (surfactant protein B) | NKX2-1 |
 | PDGFA (platelet derived growth factor A chain) | SP1, WT1 |
 | ADA (adenosine deaminase) | SP1 |
 | SA-ACT (skeletal alpha actin) | COUP-TF2 |
 | MIP (major intrinsic protein of lens fiber) | SP1 |
 | c-myb | MZF-1 |
 | COL1A2 (collagen I alpha 2) | SP1 |
 | ALDC (aldolase C) | - |
GCCCCC | TGFB1 (transforming growth factor beta 1) | SP1 and AP1 |
 | apoE (apolipoprotein E) | - |
 | c-jun | SP1 |
 | ACTC1 (actin, alpha, cardiac muscle 1) | SP1 |
 | ATF2 (activating transcription factor 2) | SP1 |
 | apoB (apolipoprotein B) | - |
 | GFAP (glial fibrillary acidic protein) | NF1, SP1 |
 | Cyclin D1 | c-Ets-2 |
 | Insulin | - |
 | ALDC (aldolase C) | - |
 | HRAS (transforming protein p21) | SP1 |
 | PFKM (muscle phosphofructokinase) | SP1 |
 | DRD1 (dopamine receptor D1) | - |
 | IGF2 (insulin-like growth factor 2) | WT1 |