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Table 7 Possible gene targets and TFs found from the TRANSFAC database for top binding motifs from Tables 5 and 6

From: Insights gained from the reverse engineering of gene networks in keloid fibroblasts

Binding Motif

Possible gene targets

Possible TFs

GGAGGG

EPO (erythropoietin)

Tf-LF1 and Tf-LF2

 

ATF2 (activating transcription factor 2)

SP1

 

RARG (retinoic acid receptor, gamma)

SP1

 

ACTC1 (actin, alpha, cardiac muscle 1)

SP1

 

FN (fibronectin)

-

 

c-myc

Pur factor

 

CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5)

SP1

 

CYP17 (cytochrome P450, subfamily XVII)

PBX1B

 

SFTPB (surfactant protein B)

NKX2-1

 

PDGFA (platelet derived growth factor A chain)

SP1, WT1

 

ADA (adenosine deaminase)

SP1

 

SA-ACT (skeletal alpha actin)

COUP-TF2

 

MIP (major intrinsic protein of lens fiber)

SP1

 

c-myb

MZF-1

 

COL1A2 (collagen I alpha 2)

SP1

 

ALDC (aldolase C)

-

GCCCCC

TGFB1 (transforming growth factor beta 1)

SP1 and AP1

 

apoE (apolipoprotein E)

-

 

c-jun

SP1

 

ACTC1 (actin, alpha, cardiac muscle 1)

SP1

 

ATF2 (activating transcription factor 2)

SP1

 

apoB (apolipoprotein B)

-

 

GFAP (glial fibrillary acidic protein)

NF1, SP1

 

Cyclin D1

c-Ets-2

 

Insulin

-

 

ALDC (aldolase C)

-

 

HRAS (transforming protein p21)

SP1

 

PFKM (muscle phosphofructokinase)

SP1

 

DRD1 (dopamine receptor D1)

-

 

IGF2 (insulin-like growth factor 2)

WT1