Figure 11
From: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
Calculated GSIR in perifused free vs. encapsulated islets. Insulin outflow calculated in response to stepwise glucose increments from 1 mM (G1) to 30 mM (G30) under normoxic (continuous line, pO2 = 140 mmHg) and slightly hypoxic (dashed line; pO2 = 45 mmHg) conditions for free (red) vs. encapsulated islets (orange). The response of normoxic free islets is the same as given in Figure 4.