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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

Figure 5

Oxygen dependence of the calculated GSIR in perifused human islets. Calculated insulin outflow in response to a stepwise glucose increment from 1 mM (G1) to 15 mM (G15) and back for different incoming oxygen concentrations as indicated by the pO2 values shown at right. For the normoxic values (red line, —), corresponding values determined experimentally (blue circles, ; redrawn from [40]) are also shown for comparison.

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