Figure 6

Influence of oxygen concentration on the insulin secretion rate of perifused islets. Data represent the fraction of normoxic (second-phase) rate at various oxygen levels in the perifusing media; experimental data (blue triangles) are from [27] and values calculated here are shown as red disks for free islets and orange circles for encapsulated islets. The size-distribution of the islet sample influences these results as larger islets are more severely affected by hypoxia.