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Figure 9 | Theoretical Biology and Medical Modelling

Figure 9

From: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

Figure 9

Comparison of oxygen levels and insulin secretion rates along a vertical cross section. Calculated values along the vertical mid-section of Figure 3 (or Figure 7) through the two perifused islets under normoxic conditions (atmospheric oxygen, 140 mmHg) (A), hypoxic conditions (resembling tissue oxygen concentrations, 45 mmHg) (B), and hypoxic conditions and encapsulation (C). The two sets of color-coded curves in each figure indicate calculated oxygen concentrations and insulin secretion rates, respectively at various time-points corresponding to glucose concentrations of 3, 5, 7, and 10 mM. At oxygen concentrations that transplanted islets are likely to encounter in their surrounding tissue (~40 mmHg), the insulin secretion of the core region of larger islets is severely compromised.

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