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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases

Figure 2

Illustrations of the translocation model for replicative DNA Pols by using interaction potentials of binding sites S 1 and S 2 with ssDNA and dsDNA segments, respectively, of a DNA substrate. (a) Top diagram shows the DNA substrate before the incorporation of the nucleotide paired with the (n+1)th base on the template. Potential V1(x) describes the interaction of the binding sites S1 with the ssDNA segment, while potential V2(x) describes the interaction of the binding sites S2 with the dsDNA segment. (b) The DNA substrate and potentials V1(x) and V2(x) after the incorporation of the nucleotide paired with the (n+1)th base on the template. (a') The DNA substrate and the potentials V1(x) and V2(x) before the incorporation of an incorrect nucleotide opposite to the (n+1)th base on the template, which is the same as (a). (b') The DNA substrate and potentials V1(x) and V2(x) after the incorporation of an incorrect nucleotide opposite to the (n+1)th base on the template.

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