Skip to main content

Table 1 Five of the 114 ZFAs with binding specificity to sites within the SIV/HIV-pol gene

From: Proviral HIV-genome-wide and pol-gene specific Zinc Finger Nucleases: Usability for targeted HIV gene therapy

Position (n)

Zif #

target-DNA sequence

Zif array α-Helix (F1;F2;F3)

21-32

1

31 tGCAGAGTGTc 21

31 aCGTCTCACAg 21

RHQHLKL; RQDNLGR; QSNVLSR

50-60

2

50 aGAAGACAGGg 60

50 tCTTCTGTCCc 60

RRAHLLN; DRGNLTR; QSNNLNR

1515-1525

56

1515 gGCAGAAGCA g 1525

1515 cCGTCTTCGTc 1525

RGQELRR; QQTNLTR; QGNTLTR

1518-1528

57

1518 a GAAGCAGAA t 1528

1518 tCTTCGTCTTa 1528

QGSNLAR; QSTTLKR; QRNNLGR

3156-3166

113

3156 cGGAGAGGCTa 3166

3156 gCCTCTCCGAt 3166

NKQALDR; RQDNLGR; QANHLSR

  1. NOTE: n is a position on a 1-to-3182 base-pair scale of the SIV/HIV-pol gene total nucleotide content, such that n+1714 (genomic context of first bp in gene) = actual genomic context of the target DNA specificity for the ZFA.
Back to article page

Theoretical Biology and Medical Modelling

ISSN: 1742-4682