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Table 1 Initial slopes β (in brackets 95% confidence interval) of the A-bomb survivors for age at exposure of 30 and attained age of 70 years and age modifying parameters γ e and γ a for different sites.

From: Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy

Site

β EAR - Japan *

β EAR - UK *

γ e

γ a

All solid

52 (43...60)

74 (61...86)

-0.024

2.38

Female breast

9.2 (6.8...12)

8.2 (6.1...11)

-0.037

1.7

Lung

7.5 (5.1...10)

8.0 (5.5...11)

0.002

4.23

Rectum

0.56 (-0.13...1.4)

0.73 (-0.17...1.8)

-0.024

2.38

Colon

8.0 (4.4...12)

7.4 (4.0...11.0)

-0.056

6.9

Mouth and pharynx

0.56 (0.2...1.2)

0.73 (0.3...1.6)

-0.024

2.38

Esophagus

0.58 (0.18...1.1)

3.2 (1.0...6.1)

-0.002+

1.9+

Stomach

9.5 (6.1...14)

5.2 (3.4...7.7)

-0.002

1.9

Small Intestine

8.0 (4.4...12)

10 (5.7...16)

-0.056

6.9

Liver

4.3 (0.0...7.2)

2.4 (0.0...4.0)

-0.021

3.6

Cervix

0.56 (0.0...1.9)

0.73 (0.0...2.5)

-0.024

2.38

Bladder

3.2 (1.1...5.4)

3.8 (1.3...6.5)

-0.024

2.38

Skin

0.35 (0.03...1.1)

0.46 (0.04...1.43)

-0.61

4.36

Brain and CNS

0.51 (0.17...0.95)

0.70 (0.23...1.31)

-0.024

2.38

Thyroid

1.2 (0.5...2.2)

0.40 (0.2...0.8)

-0.046

0.6

Salivary Gland

0.56 (0.2...1.2)

0.73 (0.26...1.6)

-0.024

2.38

Bone

-

-

-0.013

-0.56

Soft tissue

-

-

-0.013

-0.56

  1. The values for the Japanese population (β EAR - Japa n) were taken from the analysis of Preston et al. [1]. Risk was transferred to a Western population (β EAR - U K) by establishing a ERR-EAR weighting according to ICRP 103 [19].
  2. *excess cases per 10'000 PY Gy, †initial slope from colon, initial slope from oral cavity, +age dependence from stomach, age dependence from all solid