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Table 4 Results of the fits to the Hodgkin data for the different dose-response models for carcinoma induction.

From: Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy

Site Linear
(Eq.6)
Full model
(Eq.7)
No fractionation (bell shape) R = 0
(Eq.9)
Full tissue recovery (plateau) R = 1
(Eq.10)
  β CV α * R CV α * CV α * CV
All solid nc   0.089 0.17 6.4E-3 0.065 4.8E-3 0.317 8.7E-4
Female breast nc   0.044 0.15 1.1E-5 0.041 8.6E-4 0.115 1.9E-3
Lung nc   0.042 0.83 2.0E-5 0.022 1.2E-2 0.056 1.7E-3
Rectum nc   nc   8.7E-1 nc 8.7E-1 nc 8.7E-1
Colon 7.2 1.8E-4 0.001 0.99 7.1E-3 0.001 2.5E-2 0.001 2.0E-4
Mouth and pharynx nc   0.043 0.97 3.8E-4 0.017 2.0E-3 0.045 6.6E-3
Esophagus excluded
Stomach nc   0.460 0.46 8.4E-6 0.111 4.7E-3 nc 1.4E0
Small Intestine nc   0.591 0.09 3.0E-5 0.480 2.9E-5 nc 3.2E0
Liver 0.22 3.4E-3 0.323 0.29 2.6E-5 0.243 3.4E-5 0.798 4.5E-2
Cervix 1.9 5.4E-4 nc   6.2E-1 nc 6.2E-1 nc 6.2E-1
Bladder nc   0.219 0.06 1.9E-5 0.213 4.1E-4 0.633 1.0E-4
Skin 1.1 2.5E-3 nc   5.8E-1 nc 5.9E-1 nc 5.8E-1
Brain and CNS 0.44 9.8E-3 0.018 0.93 1.3E-4 0.009 4.8E-3 0.021 4.2E-3
Thyroid excluded
Salivary Gland nc   0.087 0.23 3.4E-5 0.059 4.0E-3 0.282 2.2E-4
  1. The fitted variables β, α and R are listed for each organ and each model. In addition the coefficient of variation (CV) is given. A fit corresponding to a CV > 0.05 was denoted as not converging (nc).
  2. * in Gy-1
  3. in (10,000 PY Gy)-1