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Table 4 Results of the fits to the Hodgkin data for the different dose-response models for carcinoma induction.

From: Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy

Site

Linear

(Eq.6)

Full model

(Eq.7)

No fractionation (bell shape) R = 0

(Eq.9)

Full tissue recovery (plateau) R = 1

(Eq.10)

 

β †

CV

α *

R

CV

α *

CV

α *

CV

All solid

nc

 

0.089

0.17

6.4E-3

0.065

4.8E-3

0.317

8.7E-4

Female breast

nc

 

0.044

0.15

1.1E-5

0.041

8.6E-4

0.115

1.9E-3

Lung

nc

 

0.042

0.83

2.0E-5

0.022

1.2E-2

0.056

1.7E-3

Rectum

nc

 

nc

 

8.7E-1

nc

8.7E-1

nc

8.7E-1

Colon

7.2

1.8E-4

0.001

0.99

7.1E-3

0.001

2.5E-2

0.001

2.0E-4

Mouth and pharynx

nc

 

0.043

0.97

3.8E-4

0.017

2.0E-3

0.045

6.6E-3

Esophagus

excluded

Stomach

nc

 

0.460

0.46

8.4E-6

0.111

4.7E-3

nc

1.4E0

Small Intestine

nc

 

0.591

0.09

3.0E-5

0.480

2.9E-5

nc

3.2E0

Liver

0.22

3.4E-3

0.323

0.29

2.6E-5

0.243

3.4E-5

0.798

4.5E-2

Cervix

1.9

5.4E-4

nc

 

6.2E-1

nc

6.2E-1

nc

6.2E-1

Bladder

nc

 

0.219

0.06

1.9E-5

0.213

4.1E-4

0.633

1.0E-4

Skin

1.1

2.5E-3

nc

 

5.8E-1

nc

5.9E-1

nc

5.8E-1

Brain and CNS

0.44

9.8E-3

0.018

0.93

1.3E-4

0.009

4.8E-3

0.021

4.2E-3

Thyroid

excluded

Salivary Gland

nc

 

0.087

0.23

3.4E-5

0.059

4.0E-3

0.282

2.2E-4

  1. The fitted variables β, α and R are listed for each organ and each model. In addition the coefficient of variation (CV) is given. A fit corresponding to a CV > 0.05 was denoted as not converging (nc).
  2. * in Gy-1
  3. † in (10,000 PY Gy)-1
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682