Figure 11

Cross-model validation of virulence expression in Pseudomonas agents to experiments of endogenous opioid production. This figure demonstrates the results of simulations of the production of endogenous dynorphin by GEC agents in response to a simulation of 20 minutes of ischemia, and the effects of the dynorphin production on Pseudomonas agents' levels of MvfR and HQNO production (see Additional File 5 for sample experimental referent data). Note that there is a discrepancy in the final trajectory of HQNO production between the ABM and the experimental referent. However, the effect of this discrepancy is not apparent in the following figures that demonstrate the suppression of commensal bacterial growth.