Figure 5

Schematic of P. aeruginosa virulence activation pathways due to interferon-γ, a product of host inflammation. Host cells subject to inflammation secrete the cytokine interferon-γ (IFN-γ). IFN-γ binds to outer membrane porin OprF on P. aeruginosa. Bound OprF activates RhlI, a N-(butanoyl)-L-homoserine lactone synthetase in the quorum sensing system, which in turn is required for PA-I lectin production. All the above molecular components are represented by state variables in the GMABM, and the directional arrows indicate the presence of state transition rules.