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Table 1 Literature data on the dispersion of the coagulation protein levels

From: Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. a simulation Study

protein mean sd unit c.v.
(%)
reference
II (prothrombin) 99.6 11.9 % 11.95 Yamagishi 2010 [20]
V (proaccelerin) 105.4 33.6 % 31.88 Yamagishi 2010 [20]
VII (proconvertin) 112.0 30.0 % 26.78 Folsom 1997 [21]
  130.0 33.0 % 25.38 Cushman 1996 [13]
  98.0 20.7 % 21.12 Feng 2000 [12]1, non-cvd
  99.5 26.2 % 26.33 Feng 2000 [12]1, non-thrombotic cvd
  93.6 31.7 % 33.87 Feng 2000 [12]1, thrombotic cvd
VIII 120.0 37.0 % 30.83 Cushman 1996 [13]
  127.0 40.0 % 31.50 Folsom 1997 [21]
IX 88.5 29.3 % 33.11 Yamagishi 2010 [20]
X (prothrombinase) 102.9 25.8 % 25.07 Yamagishi 2010 [20]
XI 84.1 19.7 % 23.42 Yamagishi 2010 [20]
Antithrombin-III 109.0 20.0 % 18.35 Folsom 1997 [21]
TFPI 36.4 12.8 ng/ml 35.16 Zakai 2010 [22]
  1. Literature experimental data on the dispersion of coagulation protein biological levels in the general population, as used in our simulations. In each case we computed C.V., the coefficient of variation, that is the ratio of the reported sd (standard deviation) to the reported mean. The unit used in most reports is a percentage from a standard laboratory value that is taken as 100% and is assumed close to the population average.
  2. Values marked with '1' were estimated from the standard error of the mean and the number of cases from each groups of cvd (cardiovascular disease) patients.