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Table 1 Literature data on the dispersion of the coagulation protein levels

From: Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. a simulation Study

protein

mean

sd

unit

c.v.

(%)

reference

II (prothrombin)

99.6

11.9

%

11.95

Yamagishi 2010 [20]

V (proaccelerin)

105.4

33.6

%

31.88

Yamagishi 2010 [20]

VII (proconvertin)

112.0

30.0

%

26.78

Folsom 1997 [21]

 

130.0

33.0

%

25.38

Cushman 1996 [13]

 

98.0

20.7

%

21.12

Feng 2000 [12]1, non-cvd

 

99.5

26.2

%

26.33

Feng 2000 [12]1, non-thrombotic cvd

 

93.6

31.7

%

33.87

Feng 2000 [12]1, thrombotic cvd

VIII

120.0

37.0

%

30.83

Cushman 1996 [13]

 

127.0

40.0

%

31.50

Folsom 1997 [21]

IX

88.5

29.3

%

33.11

Yamagishi 2010 [20]

X (prothrombinase)

102.9

25.8

%

25.07

Yamagishi 2010 [20]

XI

84.1

19.7

%

23.42

Yamagishi 2010 [20]

Antithrombin-III

109.0

20.0

%

18.35

Folsom 1997 [21]

TFPI

36.4

12.8

ng/ml

35.16

Zakai 2010 [22]

  1. Literature experimental data on the dispersion of coagulation protein biological levels in the general population, as used in our simulations. In each case we computed C.V., the coefficient of variation, that is the ratio of the reported sd (standard deviation) to the reported mean. The unit used in most reports is a percentage from a standard laboratory value that is taken as 100% and is assumed close to the population average.
  2. Values marked with '1' were estimated from the standard error of the mean and the number of cases from each groups of cvd (cardiovascular disease) patients.