Figure 2

Percentage of enriched biclusters. The percentage of enriched biclusters for Biological Process GO annotations (y-axis) is shown against the selected biclustering algorithms (x-axis) at different significance levels. Biclustering algorithms and k-means were applied to the Gasch dataset [19] using the parameter settings in Table 1 with GO annotations of the Biological Process category. A bicluster is said to be significantly overrepresented (enriched) with a functional category if the P-value of this functional category is lower than the preset threshold P-value. The OPSM algorithm gave a high portion of functionally enriched biclusters at all significance levels (from 85% to 100%). Next to OPSM, ISA shows relatively high portions of enriched biclusters.