Table 1 Parameters and values used in extracellular drug transport and uptake.
Parameter | Symbol | Value | Reference |
|---|---|---|---|
Free DOX diff. coefficient | kd | 0.568 mm[2]/hr | [2] |
Bound DOX diff. coefficient | kdb | 0.032 mm[2]/hr | [2] |
Rate of transmembrane transport | V1, V2 (V1 = V2) | 0.28 ng/(105 cells)/min | [4] |
Michaelis constant for transmembrane transport | k1 | 0.219 μg/ml | [4] |
Michaelis constant for transmembrane transport | k2 | 1.37 ng/(105 cells) | [4] |
Free DOX-albumin binding rate | k3 | 3000 hr-1 | [2] |
DOX-albumin dissociation rate | k4 | 1000 hr-1 | [2] |
Initial tumour cell density | Ct,0 | 106 cells/mm3 | [2] |
Tumour cell growth rate | a1 | 0.5 day-1 | Estimated |
Saturation constant in logistic equation | b | 0.02592 mm3/(105 cells)/day | Estimated |
Tumour cell natural decay rate | a2 | 0.24 day-1 | Estimated |
Tumour capillary radius | RC | 10 μm | [2] |
Tumour cord radius | RT | 120 μm | [2] |