Figure 6
From: Non-stem cancer cell kinetics modulate solid tumor progression
Comparison of tumor populations across all generational life spans at tcritical when symmetric CSC division frequency ps=10%. A) Time to simulation termination when ps = 10% and B) average population size at tcritical for all ρmax values and migration speeds. Non-zero migration values demonstrate non-monotonic behavior and distinct optima at intermediate values of replicative potential. At tcritical, model tumors from all ρmax values demonstrated a wide range of sizes. C) Matching pairs of model tumors for non-zero migration values differing only by the replicative potential of the seeding CSC. In most cases, macroscopic appearances are so similar that analysis for CSC content would be necessary to identify the replicative potential of the cell of tumor origin. Top: μ = 5, left ρmax = 2, right ρmax = 5. Middle: μ = 10, left ρmax = 3, right ρmax = 7. Bottom: μ = 15, left ρmax = 1, right ρmax = 9. Yellow CSCs enlarged for visibility.