Figure 7
From: Non-stem cancer cell kinetics modulate solid tumor progression
The relative size of the CSC compartment of model tumors is inversely proportional to the generational life span of the non-stem cancer cell progeny. Top row, ps = 1%; bottom row, ps = 10%. From left to right, μ = 0, 5, 10, and 15 cell widths/day. Model tumors seeded by CSC with low replicative potentials depended more strongly on symmetric division for macroscopic expansion and as such comprised a higher CSC fraction than those comprising deeper mortal non-stem cancer cell hierarchies. Early high amplitude fluctuations are attributable to the stochastic nature of growth, but in all cases, CSC fraction approaches a pseudo steady-state composition consistent with self-metastatic expansion.