From: Non-stem cancer cell kinetics modulate solid tumor progression
Symmetric division frequency | p s = 1% | p s = 10% | ||||||
---|---|---|---|---|---|---|---|---|
Migration rate (cell widths/day) | μ = 0 | μ = 5 | μ = 10 | μ = 15 | μ = 0 | μ = 5 | μ = 10 | μ = 15 |
Optimum ρmax (Figs. 3-4) | 0 | 5 | 7 | 8 | 0 | 3 | 5 | 5 |
tcritical (weeks) | 1303 ± 19 | 115 ± 4 | 95 ± 5 | 85 ± 6 | 130 ± 1 | 23 ± 1 | 17 ± 1 | 14 ± 1 |
CSC Fraction at optimum ρmax | 73% | 1.8% | 0.5% | 0.3% | 76% | 10% | 3.1% | 3.0% |
ρmax pairs(Figs. 5-6) | n/a | 2--8 | 3--10 | 5--10 | n/a | 2--5 | 3--7 | 1--9 |
ρmax pairs Sizes at tcritical | 1.7 × 104 | 0.86 × 104 | 2.1 × 104 | 4.0 × 104 | 3.8 × 104 | 1.9 × 104 | ||
CSC Fractions | 13%--0.37% | 6.5%--0.10% | 1.6%--0.10% | 17%--3.4% | 9.5%--1.1% | 30%--0.32% | ||
Times to 5 × 104 cells (weeks) | 140--172 | 124--196 | 102--128 | 25--25 | 18--19 | 18--21 |