Figure 11

Comparison of in silico and in vitro experiments. A. Quantitative relationships between in silico and in vitro experiments across different experimental conditions on the basis of estimated vessel areas. Data are normalized to corresponding control mean vessel areas (points and bars: mean values of vessel areas ± 95% confidence interval). sVEGFR-1(+): added sVEGFR-1, Ado(+): added Ado, Ado(+)/sVEGFR-1(+): added combination of Ado and sVEGFR-1. B. Snapshot examples of the formation of (in vitro) microtubule networks in experiments using primary human coronary artery endothelial cells (HCAEC), and conditioned medium from macrophages stimulated for 24 hours by 100 ng/mL lipopolysaccharide. In vitro control condition: VEGF ~ 50 pg/mL, sVEGFR-1~ 10 pg/mL. Experimental conditions: Ado(+): 10 μmol/L, sVEGFR-1(+): 10 ng/mL.