Diffuse intimal thickening (DIT) in proximal coronary arteries. a– Right coronary artery (RCA), 7-day-old female. b – Left anterior descending artery (LAD), 5-year-old female. c – LAD, 15-year-old female. d – LAD, 29-year-old female. Bars in a, b, c and d represent 25 μm, 50 μm, 50 μm, 100 μm, respectively. I – intima, M – media. These microscopic images represent normal morphological changes in coronary arteries from birth to adult (van Gieson stain). From: Nakashima Y, Chen YX, Kinukawa N, et al: Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age. Virchows Arch 2002, 441:279–288. Used with permission from the publisher and authors. Copyright © 2002, Springer.