Table 1 Model variables

t

years

time

E

μ g/l

generic antigen (antigenically active molecules): complexes MHC-antigenic epitopes

S

μ g/l

antigen allograft cells, which reproduce in time, non-processed form(indirect presentation)

L

μ g/l

antigen allograft cells, which reproduce in time, processed form (indirect presentation)

U

μ g/l

antigen from APCs in the allograft, not reproducing in it (direct presentation)

Y

μ g/l

antigen from APCs in the allograft, not reproducing in it, non-processed form (indirect presentation)

Z

μ g/l

antigen from APCs in the allograft, not reproducing in it, processed form (indirect presentation)

C _e

cell/μ l×10³

antigen E specific T-lymphocytes

C _l

cell/μ l×10³

antigen L specific T-lymphocytes

C _u

cell/μ l×10³

antigen U specific T-lymphocytes

C _z

cell/μ l×10³

antigen Z specific T-lymphocytes

F

ng/ml

cyclosporine

k _cac (F)

l/μ g/year

T-cells production rate (T-cells clonal expansion), antigen and lymphocyte dependent, as function of F

k _sτ

μ g/l

S entry rate at time t _τ (from reproducing cells, to be processed)

k _uτ

μ g/l

U entry rate at time t _τ (from non-reproducing cells, directly presented)

k _yτ

μ g/l

Y entry rate at time t _τ (from non-reproducing cells, to be processed)