Skip to main content

Advertisement

Table 1 Model variables

From: Modeling rejection immunity

Variables Units Description
t years time
E μ g/l generic antigen (antigenically active molecules): complexes MHC-antigenic epitopes
S μ g/l antigen allograft cells, which reproduce in time, non-processed form(indirect presentation)
L μ g/l antigen allograft cells, which reproduce in time, processed form (indirect presentation)
U μ g/l antigen from APCs in the allograft, not reproducing in it (direct presentation)
Y μ g/l antigen from APCs in the allograft, not reproducing in it, non-processed form (indirect presentation)
Z μ g/l antigen from APCs in the allograft, not reproducing in it, processed form (indirect presentation)
C e cell/μ l×103 antigen E specific T-lymphocytes
C l cell/μ l×103 antigen L specific T-lymphocytes
C u cell/μ l×103 antigen U specific T-lymphocytes
C z cell/μ l×103 antigen Z specific T-lymphocytes
F ng/ml cyclosporine
k cac (F) l/μ g/year T-cells production rate (T-cells clonal expansion), antigen and lymphocyte dependent, as function of F
k μ g/l S entry rate at time t τ (from reproducing cells, to be processed)
k μ g/l U entry rate at time t τ (from non-reproducing cells, directly presented)
k μ g/l Y entry rate at time t τ (from non-reproducing cells, to be processed)