Figure 3
From: Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans
(Estimated bioavailability of subcutaneously injected Filgrastim or Pegfilgrastim based on systematic model simulations): Bioavailability was estimated by calculating G-CSF amounts absorbed by the central compartment relative and the total amount of subcutaneously injected G-CSF (x-axis). Due to the modelled loss in the subcutaneous tissue, the bioavailability is dose-dependent. Circles indicate estimates for pharmaceutically available doses of 300μg and 480μg of Filgrastim or 6000 μg of Pegfilgrastim respectively[12, 67].