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Table 1 Major compartments of the pharmacokinetic model and corresponding regulations

From: Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans

Compartment Regulations Regulator
S proliferative fraction bone marrow content
  self-renewal probability bone marrow content
CG proliferative fraction bone marrow content
  amplification G-CSF
  transition time G-CSF
PGB amplification G-CSF
  transition time G-CSF
MGB post-mitotic amplification G-CSF
  transition time G-CSF
GRA turn-over -
G-CSF endogenous production late bone marrow cell stages
  specific degradation GRA
  external applications -
  1. Most of these compartments are mediated by G-CSF. A complete set of model equations can be found in the Additional file1.