Table 1 Major compartments of the pharmacokinetic model and corresponding regulations
From: Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans
Compartment | Regulations | Regulator |
|---|---|---|
S | proliferative fraction | bone marrow content |
| Â | self-renewal probability | bone marrow content |
CG | proliferative fraction | bone marrow content |
| Â | amplification | G-CSF |
| Â | transition time | G-CSF |
PGB | amplification | G-CSF |
| Â | transition time | G-CSF |
MGB | post-mitotic amplification | G-CSF |
| Â | transition time | G-CSF |
GRA | turn-over | - |
G-CSF | endogenous production | late bone marrow cell stages |
| Â | specific degradation | GRA |
| Â | external applications | - |