From: Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans
Parameter | Meaning | Filgrastim | Pegfilgrastim |
---|---|---|---|
k sc | subcutaneous absorption [h−1] | 0.161 | 0.107 |
k m | Michaelis-Menten constant of | 34.7 | 5.5 |
 | subcutaneous elimination [μg] |  |  |
v max | Maximum of subcutaneous | 67.3 | 16.5 |
 | elimination [h−1] |  |  |
k u | unspecific elimination [h−1] | 0.441 | 0.087 |
| Michaelis-Menten constant of | 22.4 | 30.8 |
 | specific elimination [μg] |  |  |
| Maximum of specific elimination [h−1] | 4.77 | 5.16 |
k cp | transition central to peripheral [h−1] | 0.000 | 0.075 |
k pc | transition peripheral to central [h−1] | - | 0.548 |
V D | distribution volume [l] | 1.156 | 4.091 |
| reference G-CSF serum concentration | 0.02 |