Figure 7
From: Control and inhibition analysis of complex formation processes
Behaviour of the steady state of the MMP model. (A) Complex concentration [MT 1MT 1T 2M 2] as a function of total TIMP2 concentration for different total MT1-MMP and MMP2 concentrations. Blue line indicates [MT 1] T  = 100nM, [M 2] T  = 100nM. Red line indicates [MT 1] T  = 50nM, [M 2] T  = 100nM. Green line indicates [MT 1] T  = 10nM, [M 2] T  = 100nM. Purple line indicates [MT 1] T  = 100nM, [M 2] T  = 50nM. Cyan line indicates [MT 1] T  = 100nM, [M 2] T  = 10nM. (B) Concentration map of the complex concentration [MT 1MT 1T 2M 2] as a function of total MT1-MMP and TIMP2 concentrations. Here, we set [M 2] T  = 100nM. (C) The response coefficients of the MMP model for the three interactions: the MT1-MMP dimerization, the MT1-MMP and TIMP2 binding, and the TIMP2 and MMP2 binding. The blue line shows the response coefficient RMT 1MT 1 = ∂ ln [MT 1MT 1T 2M 2]/ ∂ ln KMT 1MT 1 as a function of KMT 1MT 1, the red line shows the response coefficient RMT 1T 2 = ∂ ln [MT 1MT 1T 2M 2]/ ∂ ln KMT 1T 2 as a function of KMT 1T 2 and the green line shows the response coefficient RT 2M 2 = ∂ ln [MT 1MT 1T 2M 2]/ ∂ ln KT 2M 2 as a function of KT 2M 2. Here, we set [MT 1] T  = 100nM, [T 2] T  = 50nM and [M 2] T  = 100nM.