Figure 1

Variation in sialic acid (Sia)-recognizing Ig-superfamily lectins among primates. “Expression of CD33rSiglecs on human and great ape lymphocytes. (A) Percentage of positive lymphocytes for each Siglec Ab (staining above negative controls) for 16 chimpanzees, 5 bonobos, and 3 gorillas are shown, as well as data for 8 humans (the latter were tested on one or more occasions). Examples of flow cytometry histograms of human (B) and chimpanzee (C) lymphocytes using Abs recognizing Siglec-3, Siglec-5, Siglec-7, and Siglec-9 (y axis: normalized cell numbers expressed as percent of maximum cell number detected). In later samples examined, low levels of Siglec-11 staining (<5% positive) were occasionally detected on lymphocytes in both great apes and humans (data not shown)” [156].