Solution of the complete model over 96 hours. The simulation presents an experimental situation with high glucose infusion over 96h. The parameter p6 of glucose production was increased up to. The β‐cell mass increases due to the persisting hyperglycemia. With the adaption of β‐ cell mass, seen in Figure6a) the glucose‐insulin regulatory system is able to reach euglycemia, i.e. the stable steady state. Other parameters and initial values for this simulation are given in Tables1 and2, respectively. The solution of the complete model (9) was achieved numerically using Matlab ODE45.