Figure 1

Cellular fluid compartments. (A) Model configuration showing dyadic space, jSR, LSR, myoplasm and SL; (B) Inset provides a more detailed description of the dyadic space showing the coupling of the two types of C a^{2 +} channels (trigger and C a^{2 +} release channels) via the dyadic fluid medium. Only one representative dyadic coupling unit is shown; however the whole model contains 10,000 such identical units lumped together. The region showing interaction of the DHP-sensitive C a^{2 +} channel (I _Ca,L ) with the junctional sarcoplasmic reticulum (jSR) via the dyadic coupling unit (DCU) is highlighted (grey).